Fasting and Caloric Restriction Activate an ADIOL-NHR-91-Kynurenine Pathway Signaling Axis to Promote Healthspan

Featured from Rejuvio Facebook · 2026-05-23

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Fasting and Caloric Restriction Activate an ADIOL-NHR-91-Kynurenine Pathway Signaling Axis to Promote Healthspan. New human-aging evidence worth watching: The steroid hormone 5-androstene-3β,17β-diol (ADIOL) was discovered nearly a century ago in humans, yet its physiological functions have remained poorly understood. Using C. Result: elegans, we identify ADIOL as essential for several pro-healthspan effects of fast…

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